THE SCIENCEA FAMILIAR TARGET.
A DIFFERENT MOLECULE.
PDE4 sits at the intersection of inflammatory signaling and neuronal function. 11h was designed to reach the brain, engage this biology, and preserve room between activity and intolerance.
Scroll to understand the target, the discovery, the safety package, and the proof of concept.
WHY PDE4 MATTERS, AND WHY CNS DEVELOPMENT STALLED.
PDE4 emerges
Researchers connect PDE4 inhibition with increased intracellular cAMP and broad anti-inflammatory effects.
Rolipram teaches the limit
CNS activity appears promising, but nausea and vomiting constrain dosing and development.
The class validates
Roflumilast, apremilast, and crisaborole establish PDE4 as a druggable target in peripheral inflammatory disease.
The CNS opportunity remains
A brain-optimized molecule with a usable therapeutic window could revisit the class across neurological disease.
VISUAL DIRECTIONPDE4 ACTS LIKE A BRAKE ON CAMP SIGNALING.
PDE4 breaks down cAMP inside cells.
Blocking PDE4 can amplify anti-inflammatory and neuronal signaling.
The practical question is how much inhibition the patient can tolerate.
FROM ACADEMIC DISCOVERY TO 11H.
Tell the origin story through the molecule and the scientific problem it was designed to solve.
PDE4 emerges
Researchers connect PDE4 inhibition with increased intracellular cAMP and broad anti-inflammatory effects.
Rolipram teaches the limit
CNS activity appears promising, but nausea and vomiting constrain dosing and development.
The class validates
Roflumilast, apremilast, and crisaborole establish PDE4 as a druggable target in peripheral inflammatory disease.
The CNS opportunity remains
A brain-optimized molecule with a usable therapeutic window could revisit the class across neurological disease.
VISUAL DIRECTIONPDE4 ACTS LIKE A BRAKE ON CAMP SIGNALING.
PDE4 breaks down cAMP inside cells.
Blocking PDE4 can amplify anti-inflammatory and neuronal signaling.
The practical question is how much inhibition the patient can tolerate.